Connecting questions, methods and expertise
CRE ARTEMIS studies the causes and biology of early-onset bowel cancer through three connected themes. Each offers a different way to investigate the disease, from studying the bowel’s microbial environment to testing biological mechanisms.
A shared data and analysis hub supports connections across the programme. Our aim is to build evidence that can inform future approaches to risk assessment, prevention and earlier detection.
The gut microbiome
The bowel is home to a complex community of microorganisms. This theme investigates how the gut microbiome may influence the development of bowel cancer in younger people.
The work examines information from patient samples alongside laboratory research. It asks which microbial features deserve closer investigation, and how they might relate to the processes involved in cancer.
The aim is to understand possible mechanisms, building a stronger basis for future research into prevention and risk.
Molecular mapping
Changes within cells and tissues can provide clues about how cancer develops. This theme will create a molecular atlas spanning normal bowel tissue, early-onset polyps and bowel cancer.
An atlas brings detailed information together so researchers can compare biological patterns across different samples. Mapping these changes can help identify processes that may be important in the development of disease.
These observations can then inform questions for further testing across the programme.
Functional testing and research models
Observing a difference in a sample is a starting point. Functional testing helps researchers investigate what a suspected biological change actually does.
This theme uses preclinical research models to examine possible causes and pathways of early-onset bowel cancer. Testing specific questions under controlled conditions can help researchers assess how a proposed mechanism might work.
Laboratory findings need further investigation before they can support a change in clinical care. Our focus is on developing the evidence needed for that longer-term work.
Data and analysis across the programme
A centralised data and analysis hub supports the three research themes. Bringing complementary information together helps researchers examine connections that may be difficult to see within one type of study.
The hub is intended to strengthen both current discovery and the research that follows. Its role is to support analysis and collaboration across the centre.
Research with a patient perspective
Lived experience involvement helps connect research questions with the experiences and priorities of people affected by early-onset bowel cancer.
Our lived experience approachBuilding capability for the future
The programme includes training and mentoring to develop the next generation of researchers with skills across disciplines.
Follow the work
Find research announcements and programme updates in our news section, or explore related information in Resources.